The team prepared the liver in the machine with various drugs. In this way, it was possible to transform the liver into a good liver graft, even though it was originally not approved for transplantation. Perfusion over several days, i.e. the mechanical perfusion of the organ, enables, for example, antibiotic or hormonal therapies or the optimization of liver metabolism. In addition, lengthy laboratory or tissue tests can be carried out without time pressure. Under normal circumstances, this is not possible because organs can only be stored for 12 hours if they are stored conventionally on ice and in commercially available perfusion machines.
Treatment attempt successful
As part of an approved individual treatment attempt, the doctors gave a cancer patient on the Swisstransplant waiting list the choice of using a treated human liver. Following his consent, the organ was transplanted in May 2021. The patient was able to leave hospital a few days after the transplantation and is now doing well: “I am very grateful for the life-saving organ. Due to my rapidly progressing tumor, I had little chance of getting a liver from the waiting list within a reasonable period of time.”
Saving more lives
The article on the first transplantation of a liver preserved for several days on a perfusion machine was published in one of the most renowned scientific journals, Nature Biotechnology, on May 31, 2022. “Our therapy shows that by treating livers in the perfusion machine, it is possible to alleviate the lack of functioning human organs and save lives,” explains Prof. Pierre-Alain Clavien, Director of the Department of Visceral Surgery and Transplantation at the University Hospital Zurich (USZ). Prof. Mark Tibbitt, Professor of Macromolecular Engineering at ETH Zurich, adds: “The interdisciplinary approach to solving complex biomedical challenges embodied in this project is the future of medicine. This will allow us to use new findings even more quickly for treating patients.”
The next step in the Liver4Life project is to review the procedure on other patients and to demonstrate its efficacy and safety in the form of a multicenter study. Its success would mean that in the future, a liver transplantation, which usually constitutes an emergency procedure, would be transformed into a plannable elective procedure. At the same time, a next generation of machines is being developed. In addition, those involved in basic research continue to look for ways of treating other liver diseases outside the body with drugs, molecules or hormones.
Liver4Life: a Wyss Zurich project
The Liver4Life project was launched in 2015 under the umbrella of the Wyss Zurich Translational Center (Wyss Zurich). It brings together the highly specialized technical know-how and biomedical knowledge of around ten medical professionals, biologists and engineers. The project is being financed with donations from the initiator of Wyss Zurich, Dr. h.c. mult. Hansjörg Wyss.